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Legacy Dataset Migration to DSS

In order for NIAGADS to be in compliance with the new GDS data security standards issued by the NIH in July of 2024, NIAGADS will be decommissioning the Data Archive with the legacy data on January 25, 2025. This will ensure that all NIA funded studies can be located at one site.

Legacy datasets from the Data Archive will be inaccessible after January 25, 2025, until they are deposited into the DSS. Please see the table below for the current move status of legacy datasets.

Impacted Datasets

See a full list of impacted datasets and their migration status below:

Accession Number

Title

Location

NG00122

Prediction of Psychosis in Alzheimer Disease Summary Statistics - DeMichele-Sweet, et. al. 2021

In queue to transfer to DSS

NG00115

Similar Genetic Architecture of Alzheimer’s Disease and Differential APOE Effect Between Sexes- Wang et al. 2021

In queue to transfer to DSS

NG00112

A novel age-informed approach for genetic association analysis in Alzheimer’s disease summary statistics - Guen et al. 2021

In queue to transfer to DSS

NG00111

Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease

In queue to transfer to DSS

NG00110

Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer's disease

In queue to transfer to DSS

NG00109

Genetic architecture of subcortical brain structures in 38,851 individuals summary statistics- Satizabal et al. 2019

In queue to transfer to DSS

NG00102

Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders

DSS

NG00100

Novel risk loci and pathways associated with Alzheimer disease in African Americans: A GWAS and meta-analysis summary statistics- Kunkle et al. (2020)

Processing for DSS

NG00099

Results of gene - based weighted burden analyses using SCOREASSOC and GENEVARASSOC and multivariate analyses of variants near APOE applied to the ADSP Discovery Case - Control Based Extension Study.

In queue to transfer to DSS

NG00098

Case of CBD for determining Cryo-EM structure of 4R tau

In queue to transfer to DSS

NG00097

TARCC GWAS

In queue to transfer to DSS

NG00096

MTC GWAS

In queue to transfer to DSS

NG00095

ROSMAP2 GWAS

Processing for DSS

NG00093

WHICAP GWAS

Processing for DSS

NG00091

Results of gene-based weighted burden analyses using SCOREASSOC and GENEVARASSOC applied to the ADSP discovery sample

In queue to transfer to DSS

NG00089

CSF TREM2 Summary Statistics

In queue to transfer to DSS

NG00088

GWAS Summary Statistics of informed conditioning analysis in African Americans- Mez et al. (2017)

In queue to transfer to DSS

NG00087

WashU2 GWAS

Processing for DSS

NG00086

NACC Polygenic Hazard Score

In queue to transfer to DSS

NG00085

ExomeChip - WashU

In queue to transfer to DSS

NG00084

Immune-related genetic enrichment in FTD summary statistics- Broce et al. 2018

In queue to transfer to DSS

NG00083

Circular RNAs in Alzheimer Disease Brains - RNA-seq Data

In queue to transfer to DSS

NG00082

UAB/HudsonAlpha Families with Neurodegenerative Diseases

Processing for DSS

NG00081

CHOP Exome Chip

In queue to transfer to DSS

NG00080

Miami Exome Chip

In queue to transfer to DSS

NG00079

Northshore Exome Chip

In queue to transfer to DSS

NG00078

IGAP APOE-Stratified Analysis Summary Statistics- Jun et al. (2015)

In queue to transfer to DSS

NG00077

Genetic analyses of patients with CTE

In queue to transfer to DSS

NG00076

ADGC case-control summary statistics on 7050 samples not included in the IGAP-2013 discovery stage- Hu et al. (2019)

In queue to transfer to DSS

NG00075

IGAP Rare Variant Summary Statistics- Kunkle et al. (2019)

In queue to transfer to DSS

NG00074

Multi-cohort study of endo-lysosomal system genetics and dementia

In queue to transfer to DSS

NG00073

Genome-wide summary statistics for cognitively defined late-onset Alzheimer’s disease subgroups

In queue to transfer to DSS

NG00072

NLTCS (The National Long Term Care Survey) SNP DATA I

In queue to transfer to DSS

NG00071

ADC7 - Alzheimer Disease Center Dataset 7

DSS

NG00070

ADC6 - Alzheimer Disease Center Dataset 6

DSS

NG00069

ADC5 - Alzheimer Disease Center Dataset 5

DSS

NG00068

ADC4 - Alzheimer Disease Center Dataset 4

DSS

NG00065

ADSP Discovery Case/Control Association Results

In queue to transfer to DSS

NG00063

Prediction of Psychosis in Alzheimer Disease

In queue to transfer to DSS

NG00062

Episodic Memory Trajectories (EMTs) of 13,037 elderly

In queue to transfer to DSS

NG00061

Functional Annotation of genomic variants in studies of LOAD

In queue to transfer to DSS

NG00059

Aging, Dementia, and TBI Study

Processing for DSS

NG00058

Summary Statistics of IGAP Age at onset survival GWAS dataset - Huang KL et al. (2017)

In queue to transfer to DSS

NG00057

Laser Capture and RNA sequencing of Microglia in human brain - Mastroeni et al.(2017)

In queue to transfer to DSS

NG00056

Transethnic GWAS Summary Statistics - Jun et al. (2017)

In queue to transfer to DSS

NG00055

CSF Aβ/ptau Summary Statistics - Deming Y et al. (2017)

In queue to transfer to DSS

NG00053

IGAP Summary Statistics, ADGC subset- Lambert et al. (2013)

In queue to transfer to DSS

NG00052

CLU, A potential endophenotype for AD: Summary Statistics- Deming et al. (2016)

Processing for DSS

NG00051

SORL1 coding variants and risk for AD

In queue to transfer to DSS

NG00050

GWAS of CLU, A potential endophenotype for Alzheimer's disease

Processing for DSS

NG00049

CSF Summary Statistics- Cruchaga et al. (2013)

In queue to transfer to DSS

NG00048

ADGC Age at Onset Summary Statistics- Naj et al. (2014)

In queue to transfer to DSS

NG00047

Indianapolis African American GWAS

In queue to transfer to DSS

NG00045

Progressive Supranuclear Palsy (PSP) Summary Statistics- Hoglinger et al. (2011)

In queue to transfer to DSS

NG00043

MAYO GWAS

In queue to transfer to DSS

NG00042

Miami, Vanderbilt, and Medical School of Mount Sinai (UMVUMSSM) GWAS

In queue to transfer to DSS

NG00041

ADGC Neuropath Summary Stats and Phenotypes- Beecham et al. (2014)

In queue to transfer to DSS

NG00040

Multi-Ethnic Exome Array Study of AD, FTD, and PSP

In queue to transfer to DSS

NG00039

ADGC African American Summary Statistics- Reitz et al. (2013)

In queue to transfer to DSS

NG00038

Expression Levels from AD Case-Control Study

In queue to transfer to DSS

NG00037

Progressive Supranuclear Palsy (PSP) GWAS

Processing for DSS

NG00036

IGAP Summary Statistics- Lambert et al. (2013)

In queue to transfer to DSS

NG00035

GWAS of CSF tau levels identifies risk variants for AD

Processing for DSS

NG00034

ACT and Genetic Differences GWAS

Processing for DSS

NG00033

Identifying Rare Variants That Increase Risk For Alzheimer's Disease

In queue to transfer to DSS

NG00032

NIA-LOAD (ADGC subset) GWAS

Processing for DSS

NG00031

MIRAGE Caucasian GWAS

In queue to transfer to DSS

NG00030

WashU1 GWAS

Processing for DSS

NG00029

ROSMAP GWAS

Processing for DSS

NG00028

TGEN II GWAS

In queue to transfer to DSS

NG00027

ADGC Summary Statistics- Naj et al. (2011)

In queue to transfer to DSS

NG00026

University of Pittsburgh GWAS

Processing for DSS

NG00025

eGWAS Mayo

In queue to transfer to DSS

NG00024

ADC3- Alzheimer Disease Center Dataset 3

DSS

NG00023

ADC2- Alzheimer Disease Center Dataset 2

DSS

NG00022

ADC1- Alzheimer Disease Center Dataset 1

DSS

NG00020

NIA-LOAD GWAS

Processing for DSS

NG00017

OHSU GWAS

In queue to transfer to DSS

NG00015

Genetics Consortium for Late Onset of Alzheimers

In queue to transfer to DSS

NG00010

Caribbean Hispanic AD Study

In queue to transfer to DSS

Accessing Impacted Datasets in the DSS

Existing DSS DAR, Research Use Applies

If you have an active DSS DAR and the research use of that DAR applies to the migrated dataset, you may revise your DAR to include the migrated dataset. Please reference the “Editing an Application” section of the https://niagads.scrollhelp.site/support/pi-application-user-guide#PIApplicationUserGuide-EditinganApplication for instructions on how to revise a DAR.

No Active DSS DAR or Have an Existing DSS DAR Where Research Use Doesn’t Apply

If you do not have an active DSS DAR or the research use of an existing DSS DAR does not apply to the migrated dataset, please submit a new DAR for the migrated datasets in the DSS. Please visit https://niagads.scrollhelp.site/support/application-instructions to find information about submitting a DAR for DSS datasets.

Frequently Asked Questions

Can I still access NGXXXXX in the NIAGADS Data Archive after January 25, 2025?

No, after January 25, 2025, datasets will be inaccessible until they are available in the DSS. To access these datasets, you must submit a new Data Access Request for that dataset in the DSS or modify an existing DAR (if the research use is applicable to the dataset) in the DSS.

How can I tell if I have access to an impacted dataset?

If you recently had approved access to the dataset in the Data Archive, you should have received an email notifying you of the decommissioning with an attached of your DAR. Datasets you had access to are listed in the DAR.

If you have any issues determining which datasets you have access to in the Data Archive, please email niagads@pennmedicine.upenn.edu with your DAR ID number for assistance.

How can I tell if a dataset has been moved?

The table above will be updated continuously as datasets are migrated and a blog post will be released when datasets are moved to the DSS in the news section.

What is the anticipated timing to complete the move?

Currently the move is tentatively anticipated to be complete at the end of 2025.

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